⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503381 | 0.78 | — | — | |
| SCHEMBL9549066 | 0.78 | TSHR (0.30) | — | |
| SCHEMBL1096715 | 0.78 | TSHR (0.30) | — | |
| SCHEMBL1409240 | 0.76 | — | — | |
| SCHEMBL1500489 | 0.75 | — | — | |
| SCHEMBL442366 | 0.75 | — | — | |
| SCHEMBL1589779 | 0.75 | — | — | |
| SCHEMBL23117842 | 0.68 | — | — | |
| SCHEMBL2003443 | 0.68 | — | — | |
| SCHEMBL285592 | 0.67 | TSHR (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1602725-A2 | Abasic-nucleotide containing enzymatic nucleic acid | RIBOZYME PHARMACEUTICALS, INC. (US) | 2005-12-07 | — | — | EP | disclosed |
| US-20050147973-A1 | Immobilized probes | GE HEALTHCARE UK LIMITED (GB) | 2005-07-07 | — | — | US | disclosed |
| EP-1520038-A2 | DETECTION OF CIRCULARIZED IMMOBILIZED NUCLEIC ACID PROBES | Amersham Biosciences UK Limited (GB) | 2005-04-06 | — | — | EP | disclosed |
| US-6849726-B2 | Non-nucleotide containing RNA | SIRNA THERAPEUTICS, INC. (US) | 2005-02-01 | — | — | US | disclosed |
| WO-2003083137-A2 | DETECTION OF CIRCULARIZED IMMOBILIZED NUCLEIC ACID PROBES | AMERSHAM BIOSCIENCES UK LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |
| US-20030165969-A1 | Non-nucleotide containing enzymatic nucleic acid | RIBOZYME PHARMACEUTICALS, INC. | 2003-09-04 | — | — | US | disclosed |
| US-6555668-B2 | Comprising a non-nucleotide in a single-stranded region; hammerhead ribozyme having a non-nucleotide in the catalytic core; synthesis of abasic ribonucleoside mimetics | RIBOZYME PHARMACEUTICALS, INC. | 2003-04-29 | — | — | US | disclosed |
| US-20020193579-A1 | Non-nucleotide containing enzymatic nucleic acid | RIBOZYME PHARMACEUTICALS, INC. | 2002-12-19 | — | — | US | disclosed |
| EP-1253199-A1 | Abasic moieties containing enzymatic nucleic acids | RIBOZYME PHARMACEUTICALS, INC. (US) | 2002-10-30 | — | — | EP | disclosed |
| US-6362323-B1 | HAVING ACTIVITY TO CLEAVE AN RNA OR DNA MOLECULE | RIBOZYME PHARMACEUTICALS, INC. | 2002-03-26 | — | — | US | disclosed |
| US-6117657-A | ENZYMATIC NUCLEIC ACID MOLECULE CONTAINING ONE OR MORE NON-NUCLEOTIDE MIMETICS, AND HAVING ACTIVITY TO CLEAVE AN RNA OR DNA MOLECULE | RIBOZYME PHARMACEUTICALS, INC. (US) | 2000-09-12 | — | — | US | disclosed |
| US-5891683-A | Non-nucleotide containing enzymatic nucleic acid | RIBOZYME PHARMACEUTICALS, INC. (US) | 1999-04-06 | — | — | US | disclosed |