⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30824460 | 0.85 | — | — | |
| SCHEMBL6231124 | 0.82 | — | — | |
| SCHEMBL2405006 | 0.82 | — | — | |
| SCHEMBL6231122 | 0.76 | — | — | |
| SCHEMBL1096715 | 0.72 | TSHR (0.30) | — | |
| SCHEMBL9549066 | 0.72 | TSHR (0.30) | — | |
| SCHEMBL12707039 | 0.71 | TSHR (0.32) | — | |
| SCHEMBL383731 | 0.71 | TSHR (0.32) | — | |
| SCHEMBL204034 | 0.71 | TSHR (0.32) | — | |
| SCHEMBL4818972 | 0.69 | TSHR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220205009-A1 | MUTATED tRNA FOR CODON EXPANSION | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2022-06-30 | — | — | US | disclosed |
| EP-3904568-A1 | MUTATED TRNA FOR CODON EXPANSION | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2021-11-03 | — | — | EP | disclosed |
| WO-2020138336-A1 | MUTATED TRNA FOR CODON EXPANSION | 中外製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |
| US-9719091-B2 | Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof | PALADIN LABS, INC. (CA) | 2017-08-01 | — | — | US | disclosed |
| EP-2294195-B1 | OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF | PALADIN LABS INC (CA) | 2017-07-19 | — | — | EP | disclosed |
| EP-1986697-B1 | COMPOSITIONS AND METHODS FOR INHIBITING GENE SILENCING BY RNA INTERFERENCE | GE HEALTHCARE DHARMACON INC (US) | 2016-06-29 | — | — | EP | disclosed |
| US-20160145613-A1 | OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF | ENDO OPERATIONS LIMITED (IE) | 2016-05-26 | — | — | US | disclosed |
| US-9090649-B2 | Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof | PALADIN LABS, INC. (CA) | 2015-07-28 | — | — | US | disclosed |
| EP-2261334-B1 | Modified polynucleotides for use in RNA interference | THERMO FISHER SCIENT BIOSCIENCES INC (US) | 2014-02-26 | — | — | EP | disclosed |
| EP-1733035-B1 | MODIFIED POLYNUCLEOTIDES FOR REDUCING OFF-TARGET EFFECTS IN RNA INTERFERENCE | DHARMACON INC (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2007095387-A2 | COMPOSITIONS AND METHODS FOR INHIBITING GENE SILENCING BY RNA INTERFERENCE | DHARMACON, INC. (US) | 2007-08-23 | — | — | WO | disclosed |
| US-20070173476-A1 | MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE | DHARMACON INC. (US) | 2007-07-26 | — | — | US | disclosed |
| US-20070167384-A1 | Modified polynucleotides for use in rna interference | DHARMACON, INC. (US) | 2007-07-19 | — | — | US | disclosed |
| US-20060223777-A1 | Highly functional short hairpin RNA | DHARMACON, INC. | 2006-10-05 | — | — | US | disclosed |
| US-20060115461-A1 | Apparatus and system having dry gene silencing compositions | DHARMACON, INC. | 2006-06-01 | — | — | US | disclosed |
| US-20050223427-A1 | Modified polynucleotides for reducing off-target effects in RNA interference | DHARMACON, INC. (US) | 2005-10-06 | — | — | US | disclosed |
| US-20050176045-A1 | SNP discriminatory siRNA | DHARMACON, INC. (US) | 2005-08-11 | — | — | US | disclosed |
| US-20040249152-A1 | Method for the production of cna | NANOGEN RECOGNOMICS GMBH (DE) | 2004-12-09 | — | — | US | disclosed |
| US-20040142451-A1 | Supramolecular pairing system, its preparation and use | NANOGEN RECOGNOMICS GMBH (DE) | 2004-07-22 | — | — | US | disclosed |
| US-6689884-B1 | Supramolecular pairing system, its preparation and use | NANOGEN RECOGNOMICS GMBH (DE) | 2004-02-10 | — | — | US | disclosed |