Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 4/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820022 | 0.76 | CCNA2 (0.42) | NOS3NOS1NOS2SLC2A1AXL | |
| SCHEMBL5032214 | 0.70 | IDH2 (0.52) | AXL | |
| SCHEMBL6208888 | 0.67 | NMT1 (0.45) | MAP4K4NMT1SLC2A1 | |
| SCHEMBL1408291 | 0.66 | NR1H2 (0.49) | NOS3NOS1NOS2PIM1 | |
| SCHEMBL23605292 | 0.65 | QDPR (0.51) | NOS3NOS1NOS2 | |
| SCHEMBL1264147 | 0.64 | HTR2A (0.48) | NOS3NOS1NOS2PIM1 | |
| SCHEMBL3895116 | 0.62 | KIF11 (0.68) | KIF11CYP11B1CYP11B2 | |
| SCHEMBL22278017 | 0.62 | HRH3 (0.48) | NOS3NOS1NOS2 | |
| SCHEMBL1197491 | 0.62 | HTR2A (0.40) | MAP4K4NOS3NOS1NOS2AXL | |
| SCHEMBL4390452 | 0.61 | RPS6KB1 (0.42) | MAP4K4CYP11B1CYP11B2RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560817-A1 | METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS | Reddy US Therapeutics, Inc. (US) | 2005-08-10 | — | — | EP | claimed |
| WO-2004026844-A1 | METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS | REDDY US THERAPEUTICS, INC. (US) | 2004-04-01 | — | — | WO | claimed |