Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5907457 | 0.86 | KDM1A (0.38) | KDM4CKDM5AKDM5BGRM5 | |
| SCHEMBL5956698 | 0.84 | EGFR (0.40) | — | |
| SCHEMBL5956396 | 0.84 | CYP1A2 (0.39) | KMT2AKDM5B | |
| SCHEMBL5956373 | 0.83 | WNK1 (0.45) | MEN1KMT2ANPSR1WNK1 | |
| SCHEMBL5956595 | 0.83 | ACACA (0.43) | MEN1KMT2AMAPT | |
| SCHEMBL5956574 | 0.83 | SCN10A (0.54) | KDM4EKDM4CKDM5AKDM5BMAPT | |
| SCHEMBL5907452 | 0.81 | HDAC1 (0.50) | — | |
| SCHEMBL5907501 | 0.81 | HDAC1 (0.47) | RAB9ANPC1WNK1 | |
| SCHEMBL5956425 | 0.80 | HPGD (0.52) | RAB9AMEN1KMT2A | |
| SCHEMBL5907471 | 0.80 | ABL1 (0.51) | KDM4EKMT2AWNK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554275-A2 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004013134-A2 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-12 | — | — | WO | disclosed |