Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 8/20 | 0.34 |
| ▸ | MAOA | P21397 | 7/20 | 0.34 |
| ▸ | KDM1A | O60341 | 5/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27532466 | 0.68 | SMN1; SMN2 (0.38) | EDNRASMN1; SMN2MAPTKDM4EHPGD | |
| SCHEMBL4307405 | 0.66 | EDNRA (0.43) | EDNRASMN1; SMN2MAPTKDM4EHPGD | |
| SCHEMBL10843954 | 0.65 | SMN1; SMN2 (0.65) | EDNRASMN1; SMN2MAPTCYP1A2SLC6A3 | |
| SCHEMBL6544574 | 0.64 | SLC6A3 (0.38) | MAPTKDM4EHPGDMAOBMAOA | |
| SCHEMBL24515872 | 0.61 | EDNRA (0.39) | EDNRASMN1; SMN2MAPTCYP2C19CYP1A2 | |
| SCHEMBL10745108 | 0.61 | EDNRA (0.39) | EDNRASMN1; SMN2MAPTCYP2C19CYP1A2 | |
| SCHEMBL4000647 | 0.61 | GAA (0.41) | MAPTMAOBMAOAKDM1ACYP2C19 | |
| SCHEMBL20503289 | 0.60 | SMN1; SMN2 (0.47) | EDNRASMN1; SMN2MAPTMAOBMAOA | |
| SCHEMBL12474357 | 0.60 | SMN1; SMN2 (0.52) | EDNRASMN1; SMN2MAPTKDM4EHPGD | |
| SCHEMBL22732971 | 0.60 | SMN1; SMN2 (0.52) | EDNRASMN1; SMN2MAPTCYP1A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160219881-A1 | HERBICIDALLY ACTIVE 2-HALOGEN-4-ALKYNYL-PHENYL-PYRAZOLIDINE-DIONE OR PYRROLIDINE-DIONE DERIVATIVES | SYNGENTA LIMITED (GB) | 2016-08-04 | — | — | US | disclosed |
| EP-3046907-A1 | HERBICIDALLY ACTIVE 2-HALOGEN-4-ALKYNYL-PHENYL-PYRAZOLIDINE-DIONE OR PYRROLIDINE-DIONE DERIVATIVES | Syngenta Limited (GB) | 2016-07-27 | — | — | EP | disclosed |
| WO-2015040114-A1 | HERBICIDALLY ACTIVE 2-HALOGEN-4-ALKYNYL-PHENYL-PYRAZOLIDINE-DIONE OR PYRROLIDINE-DIONE DERIVATIVES | SYNGENTA LIMITED (GB) | 2015-03-26 | — | — | WO | disclosed |
| US-8987500-B2 | 4-biphenyl-substituted pyrazolidin-3,5-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2015-03-24 | — | — | US | disclosed |
| WO-2015032702-A1 | HERBICIDALLY ACTIVE 2-HALOGEN-4-ALKYNYL- PHENYL-PYRAZOLIDINE-DIONE OR PYRROLIDINE-DIONE DERIVATIVES | SYNGENTA LIMITED (GB) | 2015-03-12 | — | — | WO | disclosed |
| US-20140039215-A1 | 4-Biphenyl-substituted pyrazolidin-3,5-dione derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-06 | — | — | US | disclosed |
| US-8586783-B2 | 4-biphenyl-substituted pyrazolidin-3,5-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20130018202-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | BAYER CROPSCIENCE AG (DE) | 2013-01-17 | — | — | US | disclosed |
| US-8168566-B2 | 4-biphenyl-substituted pyrazolidin-3,5-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2012-05-01 | — | — | US | disclosed |
| US-8119566-B2 | use as pesticides and/or herbicides and/or microbicides; for the selective control of weeds; synergistic; low application rates and concentrations; in particular in cereals (especially wheat) | BAYER CROPSCIENCE AG (DE) | 2012-02-21 | — | — | US | disclosed |
| US-6458965-B1 | HERBICIDES, ANTIGROWTH AGENTS AND SURFACTANTS FOR WOOD PRESERVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-01 | — | — | US | disclosed |
| US-6451843-B1 | Arylphenyl-substituted cyclic keto enols | BAYER AKTIENGESELLSCHAFT (DE) | 2002-09-17 | — | — | US | disclosed |
| US-6417370-B1 | HERBICIDES, PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-09 | — | — | US | disclosed |
| CN-1298390-A | Arylphenyl-substituted cyclic keto-enols | BAYER AG (DE) | 2001-06-06 | — | — | CN | disclosed |
| EP-1075465-A1 | ARYLPHENYL-SUBSTITUTED CYCLIC KETO ENOLS | BAYER AG (DE) | 2001-02-14 | — | — | EP | disclosed |
| EP-1066258-A1 | ARYL PHENYL SUBSTITUTED CYCLIC KETOENOLS | Bayer Aktiengesellschaft (DE) | 2001-01-10 | — | — | EP | disclosed |
| EP-1056717-A1 | ARYLPHENYL-SUBSTITUTED CYCLIC KETO-ENOLS | Bayer Aktiengesellschaft (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999055673-A1 | ARYLPHENYL-SUBSTITUTED CYCLIC KETO ENOLS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-04 | — | — | WO | disclosed |
| WO-1999048869-A1 | ARYL PHENYL SUBSTITUTED CYCLIC KETOENOLS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-09-30 | — | — | WO | disclosed |
| WO-1999043649-A1 | ARYLPHENYL-SUBSTITUTED CYCLIC KETO-ENOLS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140039215-A1 | 4-Biphenyl-substituted pyrazolidin-3,5-dione derivatives | DDT, CYP4X1, HPD | EDNRA 3776/4885SMN1; SMN2 4748/4885MAPT 4472/4885 |
| US-20130018202-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | DDT, CYP4X1, HPD | EDNRA 3776/4885SMN1; SMN2 4748/4885MAPT 4472/4885 |
| US-20160219881-A1 | HERBICIDALLY ACTIVE 2-HALOGEN-4-ALKYNYL-PHENYL-PYRAZOLIDINE-DIONE OR PYRROLIDINE-DIONE DERIVATIVES | CBR3, CBR1, CNPY2 | EDNRA 1904/4885SMN1; SMN2 4648/4885MAPT 4825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.