Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234654 | 0.78 | ALDH1A1 (0.48) | ALDH1A1KDM4EPDE4BPDE4APDE4C | |
| SCHEMBL14936568 | 0.77 | MEN1 (0.57) | ALDH1A1KDM4EKMT2AMEN1PDE4B | |
| SCHEMBL27476920 | 0.76 | ALDH1A1 (0.55) | ALDH1A1KDM4EKMT2AMEN1PDE4B | |
| SCHEMBL10604420 | 0.76 | KMT2A (0.54) | ALDH1A1KDM4EKMT2AMEN1CYP2C19 | |
| SCHEMBL406034 | 0.76 | LMNA (0.59) | ALDH1A1KDM4EKMT2AMEN1TSHR | |
| SCHEMBL2642926 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KDM4EKMT2AMEN1CYP2C19 | |
| SCHEMBL6232464 | 0.73 | NPC1 (0.38) | ALDH1A1KDM4EPDE4BTSHRNPC1 | |
| SCHEMBL17709618 | 0.72 | MEN1 (0.56) | ALDH1A1KDM4EKMT2AMEN1CYP2C19 | |
| SCHEMBL30218361 | 0.72 | NPC1 (0.62) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL954173 | 0.72 | NPC1 (0.62) | ALDH1A1KDM4EKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213287-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-05-25 | — | — | EP | disclosed |
| US-6730687-B1 | THERAPY OF METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA AS AGONISTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-04 | — | — | US | disclosed |
| EP-1213287-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |