Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234654 | 0.82 | ALDH1A1 (0.48) | NPC1RAB9AATMKDM4EALDH1A1 | |
| SCHEMBL8577030 | 0.75 | ACHE (0.47) | KDM4EALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL4833864 | 0.74 | MAPT (0.58) | RAB9AATMKDM4EALDH1A1LMNA | |
| SCHEMBL18288113 | 0.73 | ALDH1A1 (0.58) | RAB9AALDH1A1PDE4BMAPK1 | |
| SCHEMBL6270450 | 0.73 | ALDH1A1 (0.50) | KDM4EALDH1A1LMNAHSD17B10MAPT | |
| SCHEMBL5623892 | 0.73 | TSHR (0.57) | NPC1RAB9AALDH1A1LMNAHSD17B10 | |
| SCHEMBL6231731 | 0.73 | ALDH1A1 (0.46) | NPC1RAB9AATMKDM4EALDH1A1 | |
| SCHEMBL20529338 | 0.72 | NPC1 (0.47) | NPC1RAB9AATMKDM4EALDH1A1 | |
| SCHEMBL11102767 | 0.72 | NR3C1 (0.62) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL15372462 | 0.72 | TUBB4A (0.56) | NPC1RAB9AATMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213287-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-05-25 | — | — | EP | disclosed |
| US-6730687-B1 | THERAPY OF METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA AS AGONISTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-04 | — | — | US | disclosed |
| EP-1213287-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |