Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CHKA | P35790 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6270316 | 0.99 | LMNA (0.58) | LMNAPOLBKMT2AHTR3ASIGMAR1 | |
| Bromide SCHEMBL6233117 | 0.99 | LMNA (0.58) | LMNAPOLBKMT2AHTR3ASIGMAR1 | |
| SCHEMBL6232404 | 0.88 | KMT2A (0.71) | KMT2AHTR3ASIGMAR1DRD4DRD2 | |
| SCHEMBL6230339 | 0.87 | DRD4 (0.68) | KMT2AHTR3ASIGMAR1DRD4DRD2 | |
| SCHEMBL27528198 | 0.86 | KMT2A (0.59) | KMT2AHTR3ASIGMAR1DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL6232393 | 0.86 | DRD4 (0.66) | KMT2AHTR3ASIGMAR1DRD4DRD2 | |
| SCHEMBL6229512 | 0.86 | MAPT (0.62) | POLBKMT2AHTR3ASIGMAR1DRD4 | |
| Bromide SCHEMBL6232178 | 0.84 | MAPT (0.61) | POLBKMT2AHTR3ASIGMAR1DRD4 | |
| Bromide SCHEMBL27477876 | 0.84 | KMT2A (0.57) | KMT2AHTR3ASIGMAR1DRD4DRD2 | |
| SCHEMBL6029911 | 0.83 | ALDH1A1 (0.67) | LMNAPOLBKMT2ADRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025097-B1 | 1-(2-NAPHTHYL) AND 1-(2-AZANAPHTHYL)-4-(1-PHENYLMETHYL)PIPERAZINES BEING DOPAMINE D 4? RECEPTOR SUBTYPE LIGANDS | NEUROGEN CORP (US) | 2005-04-27 | — | — | EP | claimed |
| US-20020013317-A1 | Certain 1- (2-naphthyl) and 1- (2- azanaphthyl) -4- (1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands | NEUROGEN CORPORATION | 2002-01-31 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013317-A1 | Certain 1- (2-naphthyl) and 1- (2- azanaphthyl) -4- (1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands | DRD2, DRD4, DRD3 | LMNA 4261/4885POLB 2307/4885KMT2A 1210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.