SCHEMBL6231955

SCHEMBL6231955

N#CCNC(=O)[C@H]1CCCN1c1cc(-c2ccccc2)ccc1N1CCNCC1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CTSB P07858 12/20 0.47
CTSS P25774 12/20 0.47
CTSL P07711 11/20 0.47
CTSK P43235 11/20 0.47
UCHL1 P09936 2/20 0.41
USP30 Q70CQ3 1/20 0.41
BACE1 P56817 1/20 0.40
HTR6 P50406 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4700759 0.84 UCHL1 (0.44) CTSBCTSSCTSLCTSKUCHL1
SCHEMBL4702383 0.83 CTSK (0.55) CTSBCTSSCTSLCTSK
SCHEMBL4702646 0.81 CTSK (0.48) CTSBCTSSCTSLCTSK
SCHEMBL4699416 0.81 CTSK (0.42) CTSBCTSSCTSLCTSKUCHL1
SCHEMBL4700127 0.81 CTSK (0.54) CTSBCTSSCTSLCTSK
SCHEMBL4698399 0.81 CTSS (0.52) CTSBCTSSCTSLCTSK
SCHEMBL4701537 0.79 CTSK (0.49) CTSBCTSSCTSLCTSK
SCHEMBL4701545 0.79 CTSK (0.49) CTSBCTSSCTSLCTSK
SCHEMBL4702085 0.79 CTSK (0.52) CTSBCTSSCTSLCTSK
SCHEMBL4701895 0.76 CTSK (0.53) CTSBCTSSCTSLCTSKBACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1372655-A4 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA INC (CA) 2005-10-12 EP disclosed
EP-1372655-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS Merck Frosst Canada & Co. (CA) 2004-01-02 EP disclosed
WO-2002069901-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA & CO. (CA) 2002-09-12 WO disclosed