SCHEMBL6232106

SCHEMBL6232106

O=C1c2[nH]c3cc(Cl)cc(Cl)c3c(=O)c2C(=O)N1Nc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
ALDH1A1 P00352 3/20 0.39
CCNB2 O95067 1/20 0.39
CDK1 P06493 1/20 0.39
CCNB1 P14635 1/20 0.39
GSK3B P49841 1/20 0.39
CCNB3 Q8WWL7 1/20 0.39
GRIN1 Q05586 3/20 0.38
GPR17 Q13304 1/20 0.38
CA12 O43570 1/20 0.38
CA9 Q16790 1/20 0.38
HPGD P15428 3/20 0.38
MAPT P10636 3/20 0.38
ALOX12 P18054 2/20 0.38
HCRTR1 O43613 1/20 0.38
S1PR4 O95977 1/20 0.38
LMNA P02545 1/20 0.38
HSP90AA1 P07900 1/20 0.38
S1PR1 P21453 1/20 0.38
CACNA1B Q00975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6239738 0.84 CA1 (0.50) CYP1A2ALDH1A1CCNB2CDK1CCNB1
SCHEMBL6231910 0.76 PIM1 (0.44) CA12CA9HPGDLMNAMEN1
SCHEMBL6231904 0.74 CA1 (0.41) CA12CA9MAPTLMNA
SCHEMBL6231125 0.73 PIM1 (0.47) CA12CA9LMNAMEN1KMT2A
SCHEMBL6232252 0.72 LMNA (0.42) CA12CA9MAPTLMNACACNA1B
SCHEMBL6233755 0.71 PIM1 (0.40) GSK3BGRIN1CA9LMNAGRIN2D
SCHEMBL6233198 0.71 CTSV (0.55) ALDH1A1CCNB2CDK1CCNB1GSK3B
SCHEMBL6232338 0.68 CA1 (0.44) ALDH1A1HPGDLMNA
SCHEMBL11945529 0.66 CYP1A2 (0.67) CYP1A2ALDH1A1GSK3BHPGDMAPT
SCHEMBL13412891 0.62 CA12 (0.49) CYP1A2ALDH1A1GSK3BGRIN1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1004582-B1 Pyridazino quinoline compounds ASTRAZENECA AB (SE) 2005-05-18 EP disclosed
EP-0790996-B1 PYRIDAZINOQUINOLINE COMPOUNDS ASTRAZENECA AB (SE) 2002-03-27 EP disclosed
US-6232313-B1 TREATING STROKE OR EPILEPTIC CONVULSIONS ASSOCIATED WITH EXCESSIVE CALCIUM INFLUX IN THE BRAIN CAUSED BY EXCITATORY AMINO ACIDS ZENECA LIMITED (GB) 2001-05-15 US disclosed
US-6214826-B1 NERVOUS SYSTEM DISORDERS ZENECA LIMITED (GB) 2001-04-10 US disclosed
EP-0724583-B1 PYRIDAZINO QUINOLINE COMPOUNDS ASTRAZENECA AB (SE) 2000-12-13 EP disclosed
EP-1004582-A2 Pyridazino quinoline compounds AstraZeneca UK Limited (GB) 2000-05-31 EP disclosed
US-5744471-A NERVOUS SYSTEM DISORDERS ZENECA LIMITED (GB) 1998-04-28 US disclosed
EP-0790996-A1 PYRIDAZINOQUINOLINE COMPOUNDS ZENECA LIMITED (GB) 1997-08-27 EP disclosed
EP-0724583-A1 PYRIDAZINO QUINOLINE COMPOUNDS ZENECA LIMITED (GB) 1996-08-07 EP disclosed
WO-1996015127-A1 PYRIDAZINOQUINOLINE COMPOUNDS ZENECA LIMITED (GB) 1996-05-23 WO disclosed
WO-1995011244-A1 PYRIDAZINO QUINOLINE COMPOUNDS ZENECA LIMITED (GB) 1995-04-27 WO disclosed