Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6230763 | 0.82 | CLK1 (0.45) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL13965487 | 0.78 | CLK1 (0.40) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL4656172 | 0.78 | HPGD (0.43) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL5165724 | 0.77 | MAOA (0.42) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL4874905 | 0.77 | CLK1 (0.41) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL6169227 | 0.77 | CLK1 (0.41) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL2328658 | 0.76 | PTGES (0.48) | HSD11B1KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL5183616 | 0.76 | CLK1 (0.40) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL4656053 | 0.76 | KDM4E (0.51) | CLK1DYRK1AIMPDH2IMPDH1KDM4E | |
| SCHEMBL14144783 | 0.75 | CLK1 (0.40) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182269-A1 | Process for the preparation of 3-cyano-1-naphthoic acid and some analogues thereof | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | US | claimed |
| EP-1517884-A1 | A PROCESS FOR THE PREPARATION OF 3-CYANO-1-NAPHTHOIC ACID AND SOME ANALOGUES THEREOF | AstraZeneca AB (SE) | 2005-03-30 | — | — | EP | claimed |
| WO-2004000792-A1 | A PROCESS FOR THE PREPARATION OF 3-CYANO-1-NAPHTHOIC ACID AND SOME ANALOGUES THEREOF | ASTRAZENECA AB (SE) | 2003-12-31 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182269-A1 | Process for the preparation of 3-cyano-1-naphthoic acid and some analogues thereof | CYP8B1, CYP51A1, NISCH | CLK1 1384/4885DYRK1A 3166/4885IMPDH2 672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.