Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169227 | 0.85 | CLK1 (0.41) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL5165724 | 0.85 | MAOA (0.42) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL5183616 | 0.84 | CLK1 (0.40) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL14144783 | 0.83 | CLK1 (0.40) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL6230763 | 0.81 | CLK1 (0.45) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL5166643 | 0.79 | CLK1 (0.40) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL6232565 | 0.77 | CLK1 (0.44) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 | |
| SCHEMBL5166743 | 0.74 | KDM4E (0.44) | IMPDH2IMPDH1NCOA3KDM4EALDH1A1 | |
| SCHEMBL4656053 | 0.72 | KDM4E (0.51) | CLK1DYRK1AIMPDH2IMPDH1KDM4E | |
| SCHEMBL13965487 | 0.71 | CLK1 (0.40) | CLK1DYRK1AIMPDH2IMPDH1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234282-A1 | 2-(Arylalkoxy)-1-Phenylethylamine Derivatives As NK1 Antagonist And Serotonin Reuptake Inhibitors | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
| US-7368448-B2 | 2-(arylalkoxy)-1-phenylethylamine derivatives as NK1 antagonist and serotonin reuptake inhibitors | ASTRAZENECA AB (SE) | 2008-05-06 | — | — | US | disclosed |
| US-20070203139-A1 | Aryl Glycinamide Derivatives And Their Use As Nk1 Antagonists And Serotonin Reuptake Inhibitors | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | US | disclosed |
| US-20070185127-A1 | 2-(Arylalkoxy)-1-phenylethylamine derivatives as nk1 antagonist and serotonin reuptake inhibitors | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| EP-1581495-B1 | 4-aryl-4-(naphth-1-ylmethylamino)methyl-piperidine compounds and their use | ASTRAZENECA AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| EP-1740553-A1 | ARYL GLYCINAMIDE DERIVATIVES AND THEIR USE AS NK1 ANTAGONISTS AND SEROTONIN REUPTAKE INHIBITHORS | AstraZeneca AB (SE) | 2007-01-10 | — | — | EP | disclosed |
| EP-1740552-A1 | 2- ( ARYLALKOXY ) -1- PHENYLETHYLAMINE DERIVATIVES AS NK1 ANTAGONIST AND SEROTONIN REUPTAKE INHIBITORS | AstraZeneca AB (SE) | 2007-01-10 | — | — | EP | disclosed |
| US-20060058352-A1 | Piperidine amine compounds and their use | ASTRAZENECA AB (SE) | 2006-03-16 | — | — | US | disclosed |
| WO-2005100324-A1 | 2- ( ARYLALKOXY ) -1- PHENYLETHYLAMINE DERIVATIVES AS NK1 ANTAGONIST AND SEROTONIN REUPTAKE INHIBITORS | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | WO | disclosed |
| WO-2005100325-A1 | ARYL GLYCINAMIDE DERIVATIVES AND THEIR USE AS NK1 ANTAGONISTS AND SEROTONIN REUPTAKE INHIBITHORS | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | WO | disclosed |
| EP-1581495-A1 | PIPERIDINE AMINE COMPOUNDS AND THEIR USE | AstraZeneca AB (SE) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004056771-A1 | PIPERIDINE AMINE COMPOUNDS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185127-A1 | 2-(Arylalkoxy)-1-phenylethylamine derivatives as nk1 antagonist and serotonin reuptake inhibitors | HTR1A, TPH1, HTR2A | CLK1 1761/4885DYRK1A 1596/4885IMPDH2 1623/4885 |
| US-20060058352-A1 | Piperidine amine compounds and their use | HRH3, H1-5, H1-0 | CLK1 4271/4885DYRK1A 4704/4885IMPDH2 1162/4885 |
| US-20070203139-A1 | Aryl Glycinamide Derivatives And Their Use As Nk1 Antagonists And Serotonin Reuptake Inhibitors | TPH1, NTSR1, HTR1D | CLK1 3649/4885DYRK1A 1071/4885IMPDH2 2796/4885 |
| US-20080234282-A1 | 2-(Arylalkoxy)-1-Phenylethylamine Derivatives As NK1 Antagonist And Serotonin Reuptake Inhibitors | HTR1A, HTR2A, TPH1 | CLK1 2143/4885DYRK1A 1650/4885IMPDH2 1555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.