Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10352170 | 0.80 | HPGD (0.37) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 | |
| SCHEMBL13951142 | 0.79 | HPGD (0.37) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 | |
| SCHEMBL3071717 | 0.78 | EPHX2 (0.61) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 | |
| SCHEMBL3068813 | 0.78 | EPHX1 (0.76) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 | |
| SCHEMBL3087394 | 0.77 | HPGD (0.57) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 | |
| SCHEMBL4461499 | 0.76 | EPHX2 (0.59) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 | |
| SCHEMBL15655475 | 0.76 | EPHX2 (0.59) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 | |
| SCHEMBL15655476 | 0.76 | EPHX2 (0.59) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 | |
| SCHEMBL26089624 | 0.76 | EPHX2 (0.59) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 | |
| SCHEMBL15655473 | 0.76 | EPHX2 (0.59) | HPGDSMN1; SMN2EPHX2EPHX1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164495-B | Covalent targeting of E3 ligases | 加利福尼亚大学董事会 | 2025-04-22 | — | — | CN | disclosed |
| US-20250120982-A1 | COVALENT TARGETING OF E3 LIGASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2025-04-17 | — | — | US | disclosed |
| US-12161648-B2 | Covalent targeting of E3 ligases | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-12-10 | — | — | US | disclosed |
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-12-02 | — | — | US | disclosed |
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-12-02 | — | — | US | disclosed |
| EP-3863642-A1 | COVALENT TARGETING OF E3 LIGASES | The Regents of the University of California (US) | 2021-08-18 | — | — | EP | disclosed |
| CN-113164495-A | Covalent targeting of E3 ligase | 加利福尼亚大学董事会 | 2021-07-23 | — | — | CN | disclosed |
| US-8524116-B2 | Multilayer sheet containing optically anisotropic layer containing liquid crystal compound and cellulose ester with polymer | FUJIFILM CORPORATION (JP) | 2013-09-03 | — | — | US | disclosed |
| US-8524116-B2 | Multilayer sheet containing optically anisotropic layer containing liquid crystal compound and cellulose ester with polymer | FUJIFILM CORPORATION (JP) | 2013-09-03 | — | — | US | disclosed |
| US-8501331-B2 | Binder composition for magnetic recording medium and magnetic recording medium | FUJIFILM CORPORATION (JP) | 2013-08-06 | — | — | US | disclosed |
| EP-0379305-B1 | Low odor adhesive compositions | MINNESOTA MINING & MFG (US) | 1994-05-11 | — | — | EP | disclosed |
| EP-0572900-A2 | Coating and its use in a process for preparing multilayer coatings | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1993-12-08 | — | — | EP | disclosed |
| US-5244899-A | Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders | G. D. SEARLE AND CO. (US) | 1993-09-14 | — | — | US | disclosed |
| US-5198435-A | Antiinflammatory, antiallergen | G. D. SEARLE & CO. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5157053-A | Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders | G. D. SEARLE & CO. (US) | 1992-10-20 | — | — | US | disclosed |
| US-5019597-A | Antiinflammatory Agents, Antiallergens | G. D. SEARLE & CO. (US) | 1991-05-28 | — | — | US | disclosed |
| US-4945006-A | UNSATURATED CYCLIC AMIDES, ANAEROBIC PROCESS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0379305-A1 | Low odor adhesive compositions | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |
| EP-0190684-B1 | BICYCLOALKYL, TRICYCLOALKYL, AZABICYCLOALKYL AND AZATRICYCLOALKYL AMIDES | G.D. Searle & Co. (US) | 1990-07-25 | — | — | EP | disclosed |
| EP-0190684-A2 | Bicycloalkyl, tricycloalkyl, azabicycloalkyl and azatricycloalkyl amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12161648-B2 | Covalent targeting of E3 ligases | RNF114, RNF4, RNF168 | HPGD 4624/4885SMN1; SMN2 1834/4885EPHX2 4228/4885 |
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | RNF114, RNF4, RNF168 | HPGD 4624/4885SMN1; SMN2 1834/4885EPHX2 4228/4885 |
| US-20250120982-A1 | COVALENT TARGETING OF E3 LIGASES | STUB1, XIAP, RBX1 | HPGD 4097/4885SMN1; SMN2 2872/4885EPHX2 2230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.