Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6232625 | 0.80 | HPGD (0.54) | HPGDSMN1; SMN2EPHX1MAPK1EPHX2 | |
| SCHEMBL13951142 | 0.74 | HPGD (0.37) | HPGDSMN1; SMN2EPHX1MAPK1EPHX2 | |
| SCHEMBL14420613 | 0.72 | HSD11B1 (0.32) | EPHX1EPHX2HSD11B1 | |
| SCHEMBL6435871 | 0.71 | FGFR1 (0.35) | SMN1; SMN2EPHX1EPHX2ALDH1A1RAB9A | |
| SCHEMBL9151004 | 0.70 | TAS1R3 (0.42) | SMN1; SMN2EPHX1MAPK1EPHX2ALDH1A1 | |
| SCHEMBL9147601 | 0.70 | TAS1R3 (0.42) | SMN1; SMN2EPHX1MAPK1EPHX2ALDH1A1 | |
| SCHEMBL8362132 | 0.70 | TAS1R3 (0.42) | SMN1; SMN2EPHX1MAPK1EPHX2ALDH1A1 | |
| SCHEMBL16676910 | 0.70 | TAS1R3 (0.56) | SMN1; SMN2EPHX1ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL12198730 | 0.69 | CPB2 (0.35) | MAPK1ALDH1A1RAB9A | |
| SCHEMBL18972296 | 0.68 | FGFR4 (0.39) | MAPK1ALDH1A1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190684-B1 | BICYCLOALKYL, TRICYCLOALKYL, AZABICYCLOALKYL AND AZATRICYCLOALKYL AMIDES | G.D. Searle & Co. (US) | 1990-07-25 | — | — | EP | disclosed |