Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533996 | 0.69 | MMP3 (0.43) | CDK5CLK2GSK3AGSK3BCDK9 | |
| SCHEMBL18966049 | 0.66 | CCNA2 (0.48) | CDK5CLK2GSK3AGSK3BCDK9 | |
| SCHEMBL10270155 | 0.66 | CCNA2 (0.51) | CDK5CLK2GSK3AGSK3BCDK9 | |
| SCHEMBL7491690 | 0.65 | ALDH1A1 (0.51) | CDK5CLK2GSK3AGSK3BCDK9 | |
| SCHEMBL6192453 | 0.63 | NPC1 (0.48) | CDK5GSK3AGSK3BCCNA2CDK2 | |
| SCHEMBL4528378 | 0.61 | NPC1 (0.61) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7488715 | 0.60 | ALDH1A1 (0.46) | CDK5CLK2GSK3AGSK3BCDK9 | |
| SCHEMBL11664173 | 0.60 | MMP3 (0.46) | CDK5CLK2GSK3AGSK3BCDK9 | |
| SCHEMBL22040024 | 0.60 | NPC1 (0.60) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL22039979 | 0.60 | NPC1 (0.60) | MAPTNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181283-B1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMA (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1181283-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075120-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-12-14 | — | — | WO | disclosed |