Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLA1 | P09884 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235697 | 0.91 | NPY5R (0.39) | MAPTSMN1; SMN2POLA1MEN1KMT2A | |
| SCHEMBL6231257 | 0.87 | MEN1 (0.42) | MAPTGAASMN1; SMN2POLA1RAB9A | |
| SCHEMBL6233025 | 0.87 | MAPT (0.42) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6235120 | 0.86 | NPY5R (0.47) | MAPTSMN1; SMN2POLA1MEN1KMT2A | |
| SCHEMBL6235953 | 0.84 | ACP1 (0.43) | MAPK14MAPTGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL6233775 | 0.83 | SLC2A1 (0.50) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6235371 | 0.83 | MAPT (0.42) | MAPTGAASMN1; SMN2POLA1MEN1 | |
| SCHEMBL6089017 | 0.80 | POLA1 (0.43) | MAPTSMN1; SMN2POLA1MEN1KMT2A | |
| SCHEMBL6234079 | 0.78 | SLC2A1 (0.50) | MAPTSMN1; SMN2ALDH1A1RAB9AMEN1 | |
| SCHEMBL6088154 | 0.78 | SLC2A1 (0.40) | MAPTGAASMN1; SMN2POLA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430030-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |