Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | TNF | P01375 | 3/20 | 0.32 |
| ▸ | HCK | P08631 | 2/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081051 | 0.82 | MAPK14 (0.54) | MAPK14TNFHCKMAPK12 | |
| SCHEMBL4092703 | 0.78 | RAF1 (0.49) | MAPK14MAPK12 | |
| SCHEMBL4092556 | 0.75 | MAPK14 (0.42) | MAPK14TNFHCKMAPK12 | |
| SCHEMBL4092124 | 0.72 | MAPK14 (0.58) | MAPK14TNFHCKMAPK12DDR2 | |
| SCHEMBL4098838 | 0.69 | MAPK14 (0.56) | MAPK14TNFHCKMAPK12DDR2 | |
| SCHEMBL5732948 | 0.56 | MAPK14 (0.63) | MAPK14TNFHCKMAPK12DDR2 | |
| SCHEMBL6162316 | 0.54 | MAPK14 (0.61) | MAPK14TNFHCKMAPK12 | |
| SCHEMBL6166487 | 0.54 | MAPK14 (0.60) | MAPK14TNFHCKMAPK12 | |
| SCHEMBL6163413 | 0.54 | MAPK14 (0.53) | MAPK14TNFHCKMAPK12 | |
| SCHEMBL6167100 | 0.53 | RAF1 (0.57) | MAPK14MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530477-A1 | COMBINATION THERAPY WITH p38 MAP KINASE INHIBITORS AND THEIR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004014387-A1 | COMBINATION THERAPY WITH p38 MAP KINASE INHIBITORS AND THEIR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-02-19 | — | — | WO | disclosed |