Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 2/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14433142 | 0.83 | ALDH1A1 (0.47) | SPRTP53PPARGSTAT3L3MBTL1 | |
| SCHEMBL14432776 | 0.82 | TP53 (0.47) | TP53IRAK4L3MBTL1CCR5LMNA | |
| SCHEMBL14432801 | 0.80 | CYP1A2 (0.41) | TP53STAT3L3MBTL1CCR5PIM1 | |
| SCHEMBL5225488 | 0.79 | TP53 (0.38) | SPRTP53IRAK4PPARGSTAT3 | |
| SCHEMBL14432861 | 0.78 | TP53 (0.43) | SPRTP53IRAK4L3MBTL1CCR5 | |
| SCHEMBL5229557 | 0.77 | HPGD (0.46) | TP53L3MBTL1LMNACYP1A2MAPT | |
| SCHEMBL5228484 | 0.76 | TP53 (0.44) | TP53IRAK4CCR5LMNAMAPT | |
| SCHEMBL14432873 | 0.76 | PPARG (0.41) | TP53PPARGSTAT3L3MBTL1CCR5 | |
| SCHEMBL14432488 | 0.76 | NAMPT (0.40) | IRAK4STAT3L3MBTL1CCR5PIM1 | |
| SCHEMBL14432816 | 0.75 | KDM4E (0.50) | TP53L3MBTL1LMNAALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581528-A1 | PIPERIDINYL-THIAZOLE CARBOXYLIC ACID DERIVATIVES AS ANGIOGENESIS INHIBITORS | Metris Therapeutics Limited (GB) | 2005-10-05 | — | — | EP | claimed |
| WO-2004058750-A1 | PIPERIDINYL-THIAZOLE CARBOXYLIC ACID DERIVATIVES AS ANGIOGENESIS INHIBITORS | METRIS THERAPEUTICS LIMITED (GB) | 2004-07-15 | — | — | WO | claimed |