SCHEMBL6233656

SCHEMBL6233656

NCc1ccc2cc([N+](=O)[O-])ccc2n1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
CYP3A4 P08684 2/20 0.48
HTR3E A5X5Y0 1/20 0.48
HTR3B O95264 1/20 0.48
CYP1A2 P05177 1/20 0.48
SLC6A4 P31645 1/20 0.48
CYP2C19 P33261 1/20 0.48
THPO P40225 1/20 0.48
HTR3A P46098 1/20 0.48
HTR3D Q70Z44 1/20 0.48
HTR3C Q8WXA8 1/20 0.48
TDP1 Q9NUW8 2/20 0.45
TSHR P16473 1/20 0.45
LOXL2 Q9Y4K0 1/20 0.44
PDK1 Q15118 1/20 0.44
TTR P02766 1/20 0.44
TXNRD1 Q16881 1/20 0.44
TXNRD3 Q86VQ6 1/20 0.44
TXNRD2 Q9NNW7 1/20 0.44
MAPT P10636 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5765507 0.84 ALDH1A1 (0.48) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2
SCHEMBL4847221 0.84 ALDH1A1 (0.48) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2
SCHEMBL31434444 0.82 MAPT (0.48) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2
SCHEMBL14127817 0.81 KDM4E (0.55) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2
SCHEMBL6271582 0.80 HTR3E (0.45) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2
SCHEMBL14094656 0.80 ALDH1A1 (0.46) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2
SCHEMBL5936119 0.80 MAPT (0.46) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2
SCHEMBL1438861 0.78 PLAU (0.53) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2
SCHEMBL14125084 0.78 KDM4E (0.45) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2
SCHEMBL8233885 0.77 ALDH1A1 (0.43) ALDH1A1CYP3A4HTR3EHTR3BCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004092181-A9 HETEROCYCLIC MCHR1 ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2005-01-27 WO disclosed