Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 6/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330359 | 0.84 | BRD4 (0.51) | RORBADORA2AADORA1EPHX2SCN4A | |
| SCHEMBL332040 | 0.82 | ALDH1A1 (0.58) | ADORA2AADORA1MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14364302 | 0.80 | RORB (0.44) | RORBADORA2AADORA1EPHX2SCN4A | |
| SCHEMBL8237626 | 0.79 | RORB (0.43) | RORBADORA2AADORA1EPHX2SCN4A | |
| SCHEMBL5048775 | 0.79 | ALDH1A1 (0.52) | RORBADORA2AADORA1XDHALDH1A1 | |
| SCHEMBL8708152 | 0.78 | RORB (0.60) | RORBADORA2AADORA1EPHX2SCN4A | |
| SCHEMBL8240373 | 0.77 | TGFBR1 (0.55) | RORBADORA2AADORA1ALDH1A1CYP1A2 | |
| SCHEMBL27837167 | 0.76 | ALDH1A1 (0.49) | RORBADORA2AADORA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27837166 | 0.75 | RORB (0.49) | RORBADORA1XDHALDH1A1SMN1; SMN2 | |
| SCHEMBL923710 | 0.75 | KDM4E (0.67) | RORBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |