Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 2/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25234206 | 0.86 | NR4A1 (0.42) | NR4A1NR4A2NR4A3PRNPALDH1A1 | |
| SCHEMBL31083578 | 0.81 | NR4A1 (0.54) | NR4A1NR4A2NR4A3PRNPALDH1A1 | |
| SCHEMBL5866499 | 0.81 | NR4A1 (0.54) | NR4A1NR4A2NR4A3PRNPALDH1A1 | |
| SCHEMBL6230409 | 0.73 | PRNP (0.49) | NR4A1NR4A2NR4A3PRNPGPR35 | |
| SCHEMBL4935698 | 0.73 | PRNP (0.51) | NR4A1NR4A2NR4A3PRNPALDH1A1 | |
| SCHEMBL30944689 | 0.73 | PRNP (0.51) | NR4A1NR4A2NR4A3PRNPALDH1A1 | |
| SCHEMBL28849239 | 0.71 | NR4A1 (0.44) | NR4A1NR4A2NR4A3PRNPALDH1A1 | |
| SCHEMBL1116170 | 0.71 | ALDH1A1 (0.60) | NR4A1NR4A2NR4A3PRNPALDH1A1 | |
| SCHEMBL16892804 | 0.69 | CYP1A2 (0.42) | NR4A2TSHRHDAC8 | |
| SCHEMBL300219 | 0.69 | ALDH1A1 (0.48) | NR4A1NR4A2NR4A3PRNPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945450-B1 | FUSED HETEROCYCLIC BENZENECARBOXYLIC ACID AMIDE DERIVATIVES AND PGD2 ANTAGONISTS CONTAINING THE SAME | SHIONOGI & CO (JP) | 2005-05-11 | — | — | EP | disclosed |
| US-6069166-A | INHIBITORY ACTIVITY AGAINST INFILTRATION OF EOSIONOPHILS, AND ARE USEFUL AS DRUGS FOR TREATING NASAL BLOCKAGE | SHIONOGI & CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0945450-A1 | FUSED HETEROCYCLIC BENZENECARBOXYLIC ACID AMIDE DERIVATIVES AND PGD2 ANTAGONISTS CONTAINING THE SAME | SHIONOGI & CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |