Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | ACP1 | P24666 | 3/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235106 | 0.89 | SMN1; SMN2 (0.69) | SMN1; SMN2TP53ACP1SLC2A1POLB | |
| SCHEMBL6236871 | 0.89 | SMN1; SMN2 (0.66) | SMN1; SMN2TP53ACP1SLC2A1POLB | |
| SCHEMBL6234851 | 0.88 | SMN1; SMN2 (0.71) | SMN1; SMN2TP53ACP1SLC2A1POLB | |
| SCHEMBL6234312 | 0.88 | SMN1; SMN2 (0.65) | SMN1; SMN2TP53ACP1SLC2A1POLB | |
| SCHEMBL6229818 | 0.86 | CCNC (0.48) | SMN1; SMN2TP53ACP1SLC2A1MEN1 | |
| SCHEMBL6234079 | 0.85 | SLC2A1 (0.50) | SMN1; SMN2TP53ACP1SLC2A1POLB | |
| SCHEMBL6231629 | 0.84 | TP53 (0.43) | SMN1; SMN2TP53ACP1SLC2A1MEN1 | |
| SCHEMBL6088873 | 0.80 | SMN1; SMN2 (0.80) | SMN1; SMN2TP53ACP1SLC2A1POLB | |
| SCHEMBL6091005 | 0.78 | SMN1; SMN2 (0.76) | SMN1; SMN2TP53ACP1SLC2A1POLB | |
| SCHEMBL6231880 | 0.78 | THRB (0.55) | SMN1; SMN2TP53ACP1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430030-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |