Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 18/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237445 | 0.85 | HTR6 (0.59) | HTR6HTR7HTR4 | |
| SCHEMBL6234179 | 0.84 | ALDH1A1 (0.60) | ALDH1A1HTR6HTR7HTR4 | |
| SCHEMBL6234028 | 0.82 | HTR6 (0.56) | HTR6HTR7HTR4 | |
| SCHEMBL6237285 | 0.81 | PDE4A (0.64) | ALDH1A1HTR6HTR7HTR4 | |
| SCHEMBL6235673 | 0.80 | PDE4A (0.62) | ALDH1A1HTR6 | |
| SCHEMBL6234462 | 0.80 | PDE4A (0.62) | ALDH1A1HTR6 | |
| SCHEMBL6235886 | 0.79 | HTR6 (0.60) | HTR6HTR7HTR4 | |
| Hydrochloric Acid SCHEMBL6237229 | 0.79 | PDE4A (0.61) | ALDH1A1HTR6HTR7HTR4 | |
| SCHEMBL6236589 | 0.78 | HTR6 (0.56) | HTR6HTR7HTR4 | |
| SCHEMBL6235655 | 0.77 | HTR6 (0.63) | HTR6HTR7HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049679-B1 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | claimed |
| EP-1049679-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-08 | — | — | EP | claimed |
| WO-1999037623-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | claimed |
| EP-1049679-B1 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | disclosed |
| US-6548504-B1 | Compounds | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-04-15 | — | — | US | disclosed |
| EP-1049679-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999037623-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | disclosed |