Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 6/20 | 0.68 |
| ▸ | NQO2 | P16083 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | G6PD | P11413 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | PGK1 | P00558 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234475 | 0.80 | RPS6KB2 (0.53) | RPS6KB2RAB9AMAPTNPC1LMNA | |
| SCHEMBL8216683 | 0.77 | RPS6KB2 (0.56) | RPS6KB2NQO2RAB9AMAPTPOLB | |
| SCHEMBL6232905 | 0.76 | RPS6KB2 (0.65) | RPS6KB2NQO2RAB9AMAPTNPC1 | |
| SCHEMBL2860819 | 0.76 | DHFR (0.54) | RPS6KB2RAB9AMAPTNPC1LMNA | |
| SCHEMBL3731976 | 0.76 | NQO2 (0.88) | NQO2RAB9AMAPTPOLBNPC1 | |
| SCHEMBL30363708 | 0.76 | NQO2 (0.88) | NQO2RAB9AMAPTPOLBNPC1 | |
| SCHEMBL10934458 | 0.74 | LMNA (0.66) | NQO2RAB9AMAPTPOLBNPC1 | |
| SCHEMBL13439501 | 0.74 | NQO2 (0.84) | NQO2RAB9AMAPTPOLBNPC1 | |
| SCHEMBL31393470 | 0.74 | RPS6KB2 (0.74) | RPS6KB2RAB9AMAPTNPC1LMNA | |
| SCHEMBL16027135 | 0.74 | RPS6KB2 (0.74) | RPS6KB2RAB9AMAPTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |