Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 16/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236246 | 0.87 | HTR6 (0.53) | HTR6 | |
| SCHEMBL6234522 | 0.86 | HTR6 (0.52) | DRD2ADRA1BHTR6 | |
| SCHEMBL6235201 | 0.84 | HTR6 (0.52) | HTR6 | |
| SCHEMBL6236033 | 0.83 | HTR6 (0.52) | HTR6 | |
| SCHEMBL31587937 | 0.82 | MEN1 (0.59) | HTR6 | |
| SCHEMBL32672558 | 0.79 | HTR6 (0.58) | HTR6 | |
| SCHEMBL32672532 | 0.78 | HTR6 (0.59) | HTR6 | |
| SCHEMBL31588485 | 0.78 | HTR6 (0.53) | HTR6 | |
| SCHEMBL6234462 | 0.77 | PDE4A (0.62) | HTTSMN1; SMN2HTR6 | |
| SCHEMBL6235673 | 0.77 | PDE4A (0.62) | HTTSMN1; SMN2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049679-B1 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | claimed |
| US-6548504-B1 | Compounds | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-04-15 | — | — | US | claimed |
| EP-1049679-B1 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | disclosed |
| US-6548504-B1 | Compounds | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-04-15 | — | — | US | disclosed |