Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 11/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.52 |
| ▸ | PRKCG | P05129 | 6/20 | 0.52 |
| ▸ | PRKCB | P05771 | 6/20 | 0.52 |
| ▸ | PRKCA | P17252 | 6/20 | 0.52 |
| ▸ | PRKCH | P24723 | 6/20 | 0.52 |
| ▸ | PRKCI | P41743 | 6/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 6/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 6/20 | 0.52 |
| ▸ | PRKACA | P17612 | 5/20 | 0.52 |
| ▸ | PRKACG | P22612 | 5/20 | 0.52 |
| ▸ | PRKACB | P22694 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238571 | 0.86 | PRKCZ (0.57) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL9541300 | 0.84 | PRKCZ (0.53) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL5662642 | 0.80 | PRKD3 (0.51) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL9543831 | 0.79 | PRKD3 (0.55) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL528390 | 0.77 | PRKCZ (1.00) | PRKCZPRKD2ROCK2ROCK1 | |
| SCHEMBL661175 | 0.77 | PRKCZ (1.00) | PRKCZPRKD2ROCK2ROCK1 | |
| SCHEMBL660022 | 0.77 | PRKCZ (1.00) | PRKCZPRKD2ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL5662171 | 0.76 | PRKCZ (0.97) | PRKCZPRKD2ROCK2ROCK1 | |
| SCHEMBL13188191 | 0.76 | PRKCZ (0.45) | PRKCZSMN1; SMN2ROCK2ROCK1HTR1A | |
| SCHEMBL17228283 | 0.76 | ROCK2 (0.64) | PRKCZPRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | claimed |
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |