Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 6/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.53 |
| ▸ | PRKCG | P05129 | 5/20 | 0.53 |
| ▸ | PRKCB | P05771 | 5/20 | 0.53 |
| ▸ | PRKCA | P17252 | 5/20 | 0.53 |
| ▸ | PRKCH | P24723 | 5/20 | 0.53 |
| ▸ | PRKCI | P41743 | 5/20 | 0.53 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.53 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | PRKACA | P17612 | 4/20 | 0.53 |
| ▸ | PRKACG | P22612 | 4/20 | 0.53 |
| ▸ | PRKACB | P22694 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5662642 | 0.92 | PRKD3 (0.51) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL5662650 | 0.86 | PRKD3 (0.43) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL6234558 | 0.84 | PRKCZ (0.63) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL9543831 | 0.84 | PRKD3 (0.55) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL6238571 | 0.84 | PRKCZ (0.57) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL6258884 | 0.76 | PRKD3 (0.46) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL6258890 | 0.76 | PRKD3 (0.46) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL10978592 | 0.75 | PRKCG (0.70) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL7481978 | 0.75 | PRKCG (0.68) | PRKCZPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL5665335 | 0.74 | P2RX7 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013072-A1 | 5-ISOQUINOLINESULFONAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITING AGENTS | ITALFARMACO S.P.A. (IT) | 1993-07-08 | — | — | WO | disclosed |