Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 2/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235513 | 0.86 | GBA1 (0.55) | GBA1SMN1; SMN2MAPTLMNACKS1B | |
| SCHEMBL6260215 | 0.85 | GBA1 (0.43) | GBA1SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL6235323 | 0.83 | GBA1 (0.40) | GBA1SMN1; SMN2FNTAFNTBKDM4E | |
| SCHEMBL6236245 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2KDM4EHSD17B10MAPTHDAC3 | |
| SCHEMBL6235489 | 0.80 | GBA1 (0.50) | GBA1SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL6241275 | 0.72 | GBA1 (0.50) | GBA1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL6231947 | 0.71 | MEN1 (0.51) | SMN1; SMN2KDM4EHSD17B10LMNAMET | |
| SCHEMBL6237662 | 0.70 | L3MBTL1 (0.43) | GBA1KDM4EHSD17B10PKMMET | |
| SCHEMBL12206782 | 0.69 | GAA (0.58) | SIGMAR1SMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL6905218 | 0.69 | KMT2A (0.60) | SIGMAR1SMN1; SMN2FNTAFNTBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |