Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 3/20 | 0.47 |
| ▸ | CKS1B | P61024 | 2/20 | 0.46 |
| ▸ | SKP1 | P63208 | 2/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260215 | 0.86 | GBA1 (0.43) | GBA1METMAPTMEN1KMT2A | |
| SCHEMBL6235747 | 0.86 | GBA1 (0.43) | GBA1METCKS1BSKP1SKP2 | |
| SCHEMBL6235489 | 0.86 | GBA1 (0.50) | GBA1METCKS1BSKP1SKP2 | |
| SCHEMBL6236245 | 0.81 | ALDH1A1 (0.45) | METMAPTMEN1KMT2ATSHR | |
| SCHEMBL13118663 | 0.76 | GPR119 (0.56) | GBA1CKS1BSKP1SKP2MAPT | |
| SCHEMBL6231947 | 0.76 | MEN1 (0.51) | METMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL31254486 | 0.75 | AKR1C3 (0.61) | GBA1METCKS1BSKP1SKP2 | |
| SCHEMBL4054998 | 0.75 | AKR1C3 (0.61) | GBA1METCKS1BSKP1SKP2 | |
| SCHEMBL2404593 | 0.74 | PTPN11 (0.59) | GBA1CKS1BSKP1SKP2MAPT | |
| SCHEMBL6237662 | 0.74 | L3MBTL1 (0.43) | GBA1METMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |