Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | BLM | P54132 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | CASP1 | P29466 | 2/20 | 0.56 |
| ▸ | CASP7 | P55210 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234984 | 0.77 | MEN1 (0.65) | TDP1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL6233715 | 0.75 | PIK3R1 (0.63) | TDP1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL6243217 | 0.75 | PIK3R1 (0.63) | TDP1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL27734202 | 0.73 | MEN1 (1.00) | TDP1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL3536096 | 0.73 | PIK3CG (0.67) | TDP1MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL2114343 | 0.72 | MAPT (1.00) | TDP1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL9352337 | 0.70 | ALOX5 (0.51) | TDP1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL3292267 | 0.70 | PIK3CG (0.47) | ALDH1A1HSD17B10TSHRPIK3CAPIK3CG | |
| SCHEMBL6947886 | 0.69 | ALOX5 (0.50) | TDP1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL5425278 | 0.69 | METAP2 (0.55) | TDP1MEN1ALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |