Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 11/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | RECQL | P46063 | 4/20 | 0.53 |
| ▸ | BLM | P54132 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | CASP7 | P55210 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6243217 | 0.82 | PIK3R1 (0.63) | PIK3R1PIK3CAMEN1ALDH1A1POLB | |
| SCHEMBL6236060 | 0.75 | TDP1 (0.56) | PIK3R1PIK3CAMEN1ALDH1A1POLB | |
| SCHEMBL6234984 | 0.74 | MEN1 (0.65) | PIK3R1PIK3CAMEN1ALDH1A1POLB | |
| SCHEMBL9866232 | 0.72 | ALOX5 (0.49) | PIK3R1PIK3CAMEN1ALDH1A1POLB | |
| SCHEMBL27734202 | 0.70 | MEN1 (1.00) | PIK3R1PIK3CAMEN1ALDH1A1POLB | |
| SCHEMBL2114343 | 0.70 | MAPT (1.00) | PIK3R1PIK3CAMEN1ALDH1A1POLB | |
| SCHEMBL7696747 | 0.70 | TDP1 (1.00) | PIK3R1PIK3CAMEN1ALDH1A1POLB | |
| SCHEMBL363259 | 0.69 | ALDH1A1 (0.68) | MEN1ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL6305829 | 0.68 | PIK3R1 (0.61) | PIK3R1PIK3CAMEN1ALDH1A1POLB | |
| SCHEMBL14829072 | 0.67 | HTT (0.39) | POLBTDP1HPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |