Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236190 | 0.87 | CLCN2 (0.50) | CLCN2MAPTPKMMAPK1SMN1; SMN2 | |
| SCHEMBL28476762 | 0.86 | MAPT (0.55) | CLCN2MAPTPKMMAPK1SMN1; SMN2 | |
| SCHEMBL7575587 | 0.84 | CLCN2 (0.49) | CLCN2MAPTPKMMAPK1SMN1; SMN2 | |
| SCHEMBL5546431 | 0.83 | MAPT (0.48) | CLCN2MAPTPKMMAPK1SMN1; SMN2 | |
| SCHEMBL13073786 | 0.79 | POLB (0.56) | CLCN2MAPTPKMMAPK1SMN1; SMN2 | |
| SCHEMBL20710895 | 0.79 | CLCN2 (0.40) | CLCN2MAPTPKMMAPK1SMN1; SMN2 | |
| SCHEMBL5391081 | 0.78 | FABP4 (0.49) | CLCN2MAPTPKMMAPK1SMN1; SMN2 | |
| SCHEMBL5697511 | 0.78 | KMT2A (0.49) | CLCN2MAPTPKMMAPK1SMN1; SMN2 | |
| SCHEMBL20710835 | 0.77 | CLCN2 (0.44) | CLCN2MAPTMAPK1SMN1; SMN2FABP4 | |
| SCHEMBL184136 | 0.77 | ALDH1A1 (0.62) | CLCN2SMN1; SMN2FABP4KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189612-A4 | VLA-4 INHIBITOR COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2005-02-16 | — | — | EP | disclosed |
| EP-1189612-A1 | VLA-4 INHIBITOR COMPOUNDS | Daiichi Pharmaceutical Co., Ltd. (JP) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001000206-A1 | VLA-4 INHIBITOR COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-04 | — | — | WO | disclosed |