Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CLCN2 | P51788 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236192 | 0.83 | CLCN2 (0.50) | MAPTPKMMAPK1SMN1; SMN2CLCN2 | |
| SCHEMBL28476762 | 0.82 | MAPT (0.55) | MAPTPKMMAPK1SMN1; SMN2CLCN2 | |
| SCHEMBL1899962 | 0.77 | KMT2A (0.54) | MAPTPKMCLCN2FABP4ALDH1A1 | |
| SCHEMBL6236190 | 0.76 | CLCN2 (0.50) | MAPTPKMMAPK1SMN1; SMN2CLCN2 | |
| SCHEMBL13073786 | 0.76 | POLB (0.56) | MAPTPKMMAPK1SMN1; SMN2CLCN2 | |
| SCHEMBL2413633 | 0.74 | TSHR (0.52) | MAPTMAPK1SMN1; SMN2CLCN2FABP4 | |
| SCHEMBL184136 | 0.73 | ALDH1A1 (0.62) | SMN1; SMN2CLCN2FABP4ALDH1A1HPGD | |
| SCHEMBL16181442 | 0.72 | FABP4 (0.50) | MAPTCLCN2FABP4ALDH1A1HPGD | |
| SCHEMBL21722620 | 0.72 | KDM4E (0.48) | MAPTMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL13073788 | 0.72 | NPC1 (0.53) | MAPTSMN1; SMN2CLCN2FABP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651641-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-05-23 | — | — | EP | disclosed |