SCHEMBL6236293

SCHEMBL6236293

CCC(C(C)=O)C(=O)O.CCOC(=O)c1nc2c(nc1C)CCCC2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.39
CYP2C9 P11712 1/20 0.39
KDM4E B2RXH2 4/20 0.39
ACHE P22303 8/20 0.37
CACNB4 O00305 2/20 0.35
CACNA1A O00555 2/20 0.35
CACNA1G O43497 2/20 0.35
CACNG3 O60359 2/20 0.35
CACNA1F O60840 2/20 0.35
CACNA1H O95180 2/20 0.35
CACNB3 P54284 2/20 0.35
CACNA2D1 P54289 2/20 0.35
CACNG7 P62955 2/20 0.35
CACNA1B Q00975 2/20 0.35
CACNA1D Q01668 2/20 0.35
CACNB1 Q02641 2/20 0.35
CACNG1 Q06432 2/20 0.35
CACNB2 Q08289 2/20 0.35
CACNA1S Q13698 2/20 0.35
CACNA1C Q13936 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5880357 0.86 KDM4E (0.48) CYP1A2CYP2C9KDM4EACHECACNB4
SCHEMBL6236301 0.76 ACHE (0.38) CYP1A2CYP2C9KDM4EACHECACNB4
SCHEMBL26617701 0.73 KDM4E (0.47) CYP1A2CYP2C9KDM4EACHEALDH1A1
SCHEMBL30681964 0.73 KDM4E (0.47) CYP1A2CYP2C9KDM4EACHEALDH1A1
SCHEMBL26617997 0.72 KDM4E (0.46) CYP1A2KDM4EACHECACNB4CACNA1A
SCHEMBL31345638 0.72 KDM4E (0.46) CYP1A2KDM4EACHECACNB4CACNA1A
SCHEMBL9014873 0.71 KDM4E (0.45) CYP1A2KDM4EACHECACNB4CACNA1A
SCHEMBL21572852 0.70 ALDH1A1 (0.56) CYP1A2KDM4EALDH1A1NPC1RAB9A
SCHEMBL2410364 0.69 KDM4E (0.41) CYP1A2CYP2C9KDM4EACHEALDH1A1
SCHEMBL2408933 0.69 KDM4E (0.41) CYP1A2CYP2C9KDM4EACHEALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1587796-A1 SATURATED QUINOXALINE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS AstraZeneca AB (SE) 2005-10-26 EP disclosed
WO-2004069813-A1 SATURATED QUINOXALINE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS ASTRAZENECA AB (SE) 2004-08-19 WO disclosed