Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.48 |
| ▸ | FPR1 | P21462 | 1/20 | 0.45 |
| ▸ | GNRHR | P30968 | 1/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | HNF4A | P41235 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238178 | 0.89 | RXRA (0.56) | RXRACYP3A4RXRBRXRGCYP26A1 | |
| SCHEMBL6244434 | 0.89 | RXRA (0.70) | RXRACYP3A4RXRBRXRGCYP26A1 | |
| SCHEMBL6240226 | 0.88 | RXRA (0.51) | RXRACYP3A4RXRBRXRGCYP26A1 | |
| SCHEMBL6245896 | 0.87 | RXRA (0.51) | RXRACYP3A4RXRBRXRGCYP26A1 | |
| SCHEMBL6237264 | 0.87 | RXRA (0.51) | RXRACYP3A4RXRBRXRGCYP26A1 | |
| SCHEMBL6903012 | 0.86 | RXRA (0.74) | RXRACYP3A4RXRBRXRGCYP26A1 | |
| SCHEMBL6241202 | 0.86 | RXRA (0.56) | RXRACYP3A4RXRBRXRGCYP26A1 | |
| SCHEMBL6242960 | 0.84 | RXRA (0.47) | RXRACYP3A4RXRBRXRGCYP26A1 | |
| SCHEMBL6238864 | 0.84 | RXRA (0.48) | RXRACYP3A4RXRBRXRGCYP26A1 | |
| SCHEMBL8016720 | 0.79 | CYP3A4 (0.56) | RXRACYP3A4RXRBRXRGCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |