Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.48 |
| ▸ | HNF4A | P41235 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6245896 | 0.97 | RXRA (0.51) | RXRAHNF4ACYP3A4PPARGNR1H3 | |
| SCHEMBL6237264 | 0.93 | RXRA (0.51) | RXRAHNF4ACYP3A4CYP26A1RXRB | |
| SCHEMBL6244973 | 0.89 | RXRA (0.61) | RXRAHNF4APPARGNR1H3RXRB | |
| SCHEMBL6238178 | 0.88 | RXRA (0.56) | RXRAHNF4ACYP3A4CYP26A1RXRB | |
| SCHEMBL6241810 | 0.86 | RXRA (0.65) | RXRAHNF4APPARGNR1H3RXRB | |
| SCHEMBL6236296 | 0.84 | RXRA (0.55) | RXRAHNF4ACYP3A4CYP26A1RXRB | |
| SCHEMBL6240822 | 0.81 | RXRA (0.65) | RXRAHNF4ACYP3A4CYP26A1RXRB | |
| SCHEMBL6240226 | 0.81 | RXRA (0.51) | RXRAHNF4ACYP3A4PPARGCYP26A1 | |
| SCHEMBL6241202 | 0.79 | RXRA (0.56) | RXRAHNF4ACYP3A4CYP26A1RXRB | |
| SCHEMBL6903012 | 0.79 | RXRA (0.74) | RXRACYP3A4CYP26A1RXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |