Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.47 |
| ▸ | HNF4A | P41235 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6245896 | 0.96 | RXRA (0.51) | RXRACYP3A4CYP26A1HNF4ARXRB | |
| SCHEMBL6238864 | 0.93 | RXRA (0.48) | RXRACYP3A4CYP26A1HNF4ARXRB | |
| SCHEMBL6238178 | 0.91 | RXRA (0.56) | RXRACYP3A4CYP26A1HNF4ARXRB | |
| SCHEMBL6240822 | 0.89 | RXRA (0.65) | RXRACYP3A4CYP26A1HNF4ARXRB | |
| SCHEMBL6236296 | 0.87 | RXRA (0.55) | RXRACYP3A4CYP26A1HNF4ARXRB | |
| SCHEMBL8896825 | 0.85 | RXRA (0.63) | RXRACYP3A4CYP26A1HNF4ARXRB | |
| SCHEMBL6241810 | 0.84 | RXRA (0.65) | RXRAHNF4ARXRBRXRG | |
| SCHEMBL6240226 | 0.83 | RXRA (0.51) | RXRACYP3A4CYP26A1HNF4ARXRB | |
| SCHEMBL6244973 | 0.81 | RXRA (0.61) | RXRAHNF4ARXRBRXRG | |
| SCHEMBL6241202 | 0.81 | RXRA (0.56) | RXRACYP3A4CYP26A1HNF4ARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |