SCHEMBL6236314

SCHEMBL6236314

Nc1ccc2c(ccn2S(=O)(=O)c2cccc(F)c2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 14/20 0.52
MET P08581 1/20 0.48
POLB P06746 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
MEN1 O00255 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
HPGD P15428 1/20 0.47
TSHR P16473 1/20 0.47
HTT P42858 1/20 0.47
KMT2A Q03164 1/20 0.47
EPHX2 P34913 2/20 0.46
PPARG P37231 2/20 0.46
HDAC3 O15379 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
BRD4 O60885 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2510832 0.84 HTR6 (0.68) HTR6POLBL3MBTL1MEN1ALDH1A1
SCHEMBL29617199 0.84 HTR6 (0.68) HTR6POLBL3MBTL1MEN1ALDH1A1
Hydroxyamine SCHEMBL14672692 0.82 HTR6 (0.65) HTR6POLBL3MBTL1MEN1ALDH1A1
SCHEMBL6236469 0.80 MET (0.52) HTR6METPOLBL3MBTL1MEN1
SCHEMBL426117 0.79 HTR6 (0.68) HTR6POLBL3MBTL1MEN1ALDH1A1
SCHEMBL1972911 0.78 HTR6 (0.50) HTR6POLBL3MBTL1MEN1ALDH1A1
SCHEMBL3327051 0.78 HTR6 (0.45) HTR6POLBL3MBTL1EPHX2PPARG
SCHEMBL1974915 0.77 HTR6 (0.70) HTR6METPOLBL3MBTL1MEN1
SCHEMBL482811 0.76 HTR6 (0.60) HTR6POLBL3MBTL1MEN1ALDH1A1
SCHEMBL4321450 0.76 HTR6 (0.64) HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005007083-A2 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2005-01-27 WO disclosed