⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4829868 | 0.66 | KMT2A (0.37) | — | |
| SCHEMBL5652264 | 0.60 | — | — | |
| SCHEMBL11581743 | 0.60 | NOS2 (0.35) | — | |
| SCHEMBL10959340 | 0.60 | KCNN4 (0.34) | — | |
| SCHEMBL168935 | 0.59 | PDGFRA (0.52) | — | |
| SCHEMBL29848588 | 0.59 | MAPT (0.38) | — | |
| SCHEMBL1996673 | 0.59 | MAPT (0.38) | — | |
| SCHEMBL8333405 | 0.57 | GAA (0.31) | — | |
| SCHEMBL156862 | 0.57 | MAPT (0.41) | — | |
| SCHEMBL29353131 | 0.57 | MAPT (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140170159-A9 | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof | HALOZYME, INC. | 2014-06-19 | — | — | US | disclosed |
| US-20130266579-A1 | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof | WEI GE (US) | 2013-10-10 | — | — | US | disclosed |
| EP-1608663-A1 | PYRROLO (2,1-C)(1,4) BENZODIAZEPINES DIMERS AS ANTITUMOUR AGENTS AND PROCESS THEREOF | Council of Scientific and Industrial Research (IN) | 2005-12-28 | — | — | EP | disclosed |
| EP-1608650-A1 | PYRENE-LINKED PYRROLO(2,1-C)(1,4)BENZODIAZEPINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Council of Scientific and Industrial Research (IN) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004087716-A1 | PYRROLO[(2,1-C)(1,4) BENZODIAZEPINES DIMERS AS ANTITUMOUR AGENTS AND PROCESS THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004087711-A1 | PYRENE-LINKED PYRROLO (2,1-C) (1,4) BENZODIAZEPINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | COUNCIL OF SCENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-10-14 | — | — | WO | disclosed |