SCHEMBL6236525

SCHEMBL6236525

COc1ccc(CC2SC(=O)NC2=O)cc1C(=O)NCc1cccc(OC(F)(F)F)c1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 2/20 0.49
ROCK1 Q13464 2/20 0.49
PPARA Q07869 5/20 0.49
PPARD Q03181 2/20 0.49
KCNB1 Q14721 1/20 0.48
PPARG P37231 5/20 0.47
MPC2 O95563 1/20 0.47
CYP2C8 P10632 1/20 0.47
CYP2C9 P11712 1/20 0.47
PTPN1 P18031 2/20 0.46
MMP13 P45452 1/20 0.46
MAPK14 Q16539 1/20 0.45
LMNA P02545 2/20 0.44
HPGD P15428 2/20 0.44
CACNA1G O43497 1/20 0.43
CACNA1H O95180 1/20 0.43
CACNA1I Q9P0X4 1/20 0.43
FFAR1 O14842 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6239522 0.88 PPARA (0.59) ROCK2ROCK1PPARAPPARDPPARG
SCHEMBL13524847 0.86 PTPN1 (0.51) PPARAPPARGMPC2CYP2C8CYP2C9
SCHEMBL13847879 0.86 PTPN1 (0.51) ROCK2ROCK1PPARAPPARGMPC2
SCHEMBL6378335 0.84 FFAR1 (0.55) ROCK2ROCK1PPARAPPARGPTPN1
SCHEMBL20125593 0.84 PPARA (0.61) PPARAPPARDPPARGPTPN1
SCHEMBL3922 0.84 PPARA (0.61) PPARAPPARDPPARGPTPN1
SCHEMBL14379043 0.84 PPARA (0.61) PPARAPPARDPPARGPTPN1
SCHEMBL29358494 0.84 PPARA (0.61) PPARAPPARDPPARGPTPN1
SCHEMBL6378019 0.83 PPARG (0.58) PPARAPPARDPPARGMPC2CYP2C8
SCHEMBL13847878 0.83 PPARA (0.47) PPARAPPARDPPARGMPC2CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1207158-B1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN SEIYAKU KK (JP) 2005-05-25 EP claimed
US-6780431-B1 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONISTS; METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA KYORIN PHARMACEUTICAL CO., LTD. (JP) 2004-08-24 US claimed
EP-1207158-A1 SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES KYORIN PHARMACEUTICAL CO., LTD. (JP) 2002-05-22 EP claimed