Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.57 |
| ▸ | HNF4A | P41235 | 10/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RARA | P10276 | 2/20 | 0.43 |
| ▸ | RARB | P10826 | 2/20 | 0.43 |
| ▸ | RARG | P13631 | 2/20 | 0.43 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239175 | 0.82 | RXRA (0.67) | RXRAHNF4ALMNARARARARB | |
| SCHEMBL6243783 | 0.77 | HNF4A (0.60) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL6242094 | 0.75 | HNF4A (0.57) | RXRAHNF4ALMNARARARARB | |
| SCHEMBL6243129 | 0.75 | RXRA (0.55) | RXRAHNF4ALMNARARARARB | |
| SCHEMBL6914152 | 0.73 | RXRA (1.00) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL6242408 | 0.73 | RXRA (0.59) | RXRAHNF4ALMNARARGHCRTR1 | |
| SCHEMBL6240826 | 0.73 | RXRA (0.58) | RXRAHNF4ALMNARARARARB | |
| SCHEMBL6239279 | 0.72 | RXRA (0.58) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL6242707 | 0.72 | RXRA (0.50) | RXRAHNF4ALMNARARARARB | |
| SCHEMBL6241850 | 0.72 | RXRA (0.55) | RXRAHNF4ARARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |