Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 3/20 | 0.60 |
| ▸ | RXRA | P19793 | 11/20 | 0.53 |
| ▸ | RARG | P13631 | 6/20 | 0.53 |
| ▸ | RARB | P10826 | 5/20 | 0.53 |
| ▸ | RARA | P10276 | 4/20 | 0.53 |
| ▸ | RXRB | P28702 | 2/20 | 0.53 |
| ▸ | RXRG | P48443 | 2/20 | 0.53 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6244136 | 0.81 | RXRA (0.62) | RXRARARGRARBRARARXRB | |
| SCHEMBL6242159 | 0.78 | HNF4A (0.48) | HNF4ARXRARARGRARBRARA | |
| SCHEMBL6236530 | 0.77 | RXRA (0.57) | HNF4ARXRARARGRARBRARA | |
| SCHEMBL6236924 | 0.77 | CDC25B (0.59) | HNF4ARXRARARGRARBRARA | |
| SCHEMBL6901726 | 0.76 | RXRA (0.69) | RXRARARGRARBRARARXRB | |
| SCHEMBL6242642 | 0.74 | HNF4A (0.68) | HNF4ARXRARARGRARBRARA | |
| SCHEMBL9551769 | 0.74 | HNF4A (0.55) | HNF4ARXRARARGRARBRARA | |
| SCHEMBL2128581 | 0.73 | RXRA (0.68) | RXRARARGRARBRARARXRB | |
| SCHEMBL29440075 | 0.73 | RXRA (0.68) | RXRARARGRARBRARARXRB | |
| SCHEMBL292500 | 0.73 | RXRA (0.83) | HNF4ARXRARARGRARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |