Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | NAT1 | P18440 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3885747 | 0.89 | MAOB (0.42) | SMN1; SMN2CA12CA9RAB9ACNR2 | |
| SCHEMBL21810508 | 0.85 | CNR1 (0.55) | SMN1; SMN2CA12CA9RAB9AKMT2A | |
| SCHEMBL8820277 | 0.84 | HDAC7 (0.41) | KMT2ACNR2 | |
| SCHEMBL3151094 | 0.83 | HDAC7 (0.49) | HSP90AA1SMN1; SMN2NPSR1CA12CA9 | |
| SCHEMBL776571 | 0.83 | MAPT (0.44) | ESR2HSP90AA1SMN1; SMN2NPSR1RAB9A | |
| SCHEMBL8082279 | 0.81 | MAOA (0.41) | CA9KMT2ASLC9A1 | |
| SCHEMBL30368404 | 0.81 | KDM4E (0.35) | SMN1; SMN2NPSR1KMT2A | |
| SCHEMBL11587245 | 0.81 | S1PR4 (0.45) | SMN1; SMN2RAB9ACNR2 | |
| SCHEMBL2315622 | 0.81 | MAOB (0.49) | HSP90AA1HSP90AB1SMN1; SMN2RAB9A | |
| SCHEMBL10459345 | 0.80 | CHRM1 (0.51) | CHRM1PGRNR3C1NR3C2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009384-A2 | EGFR TYROSINE KINASE INHIBITORS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |