Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6370511 | 0.77 | NPC1 (0.58) | MAPK14ALDH1A1NPC1RAB9APAX8 | |
| SCHEMBL6378562 | 0.74 | MAPK14 (0.55) | MAPK14ALDH1A1NPC1RAB9APAX8 | |
| SCHEMBL6901757 | 0.74 | NPC1 (0.59) | MAPK14ALDH1A1NPC1RAB9APAX8 | |
| SCHEMBL11732101 | 0.70 | RAB9A (0.64) | MAPK14ALDH1A1NPC1RAB9APAX8 | |
| SCHEMBL6370976 | 0.68 | MAPK14 (0.78) | MAPK14ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6376389 | 0.68 | MAPK14 (0.68) | MAPK14ALDH1A1NPC1RAB9APAX8 | |
| SCHEMBL15542499 | 0.67 | LDHA (0.53) | MAPK14ALDH1A1SMN1; SMN2 | |
| SCHEMBL6232421 | 0.66 | MAPK14 (0.73) | MAPK14ALDH1A1LMNA | |
| SCHEMBL25368518 | 0.66 | MAPK14 (0.43) | MAPK14 | |
| SCHEMBL6273207 | 0.66 | MAPK14 (0.57) | MAPK14ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007632-A1 | SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38 | PHARMACIA CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |
| EP-1470112-A1 | SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38 | Pharmacia Corporation (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003059891-A1 | SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38 | PHARMACIA CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |