Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743412 | 0.74 | RAB9A (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6237072 | 0.74 | MAPK14 (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9026724 | 0.73 | RAB9A (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5067628 | 0.73 | SMN1; SMN2 (0.59) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL134480 | 0.71 | RAB9A (0.70) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5842939 | 0.71 | RAB9A (0.70) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27619397 | 0.71 | RAB9A (0.70) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4046802 | 0.70 | NPC1 (0.54) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29750323 | 0.69 | ALDH1A1 (0.54) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10683662 | 0.69 | SMN1; SMN2 (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470112-A1 | SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38 | Pharmacia Corporation (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003059891-A1 | SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38 | PHARMACIA CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |