Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5644665 | 0.75 | MTNR1A (0.43) | MAP2K1MTNR1AIDO1ALDH1A1PKM | |
| Bromide SCHEMBL6207122 | 0.74 | MTNR1A (0.43) | MAP2K1MTNR1AIDO1ALDH1A1PKM | |
| SCHEMBL6237420 | 0.70 | MAP2K1 (0.42) | MAP2K1MTNR1AIDO1ALDH1A1PKM | |
| SCHEMBL3343411 | 0.68 | PSEN1 (0.41) | MAP2K1MEN1KMT2A | |
| SCHEMBL2656685 | 0.66 | MTNR1A (0.42) | MTNR1AIDO1PKMMEN1KMT2A | |
| SCHEMBL8796437 | 0.60 | KDM1A (0.43) | MTNR1AIDO1ALDH1A1TSHRMAPT | |
| SCHEMBL9209417 | 0.59 | EPHX1 (0.40) | MTNR1AIDO1ALDH1A1PKMMEN1 | |
| SCHEMBL6528518 | 0.59 | CACNA2D1 (0.48) | MEN1KMT2AMAPTSLC6A4 | |
| SCHEMBL6239173 | 0.59 | MAP2K1 (0.43) | MAP2K1ALDH1A1KDM1AHTTHSD17B10 | |
| SCHEMBL27524328 | 0.58 | IDO1 (0.54) | MTNR1AIDO1ALDH1A1PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554250-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004031154-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |