Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3342697 | 0.80 | PSEN1 (0.39) | MAP2K1SIGMAR1 | |
| SCHEMBL3344738 | 0.80 | PSEN1 (0.49) | — | |
| SCHEMBL3343411 | 0.76 | PSEN1 (0.41) | MAP2K1MEN1KMT2A | |
| SCHEMBL5644665 | 0.73 | MTNR1A (0.43) | MAP2K1MAPTMAPK1TDP1HTT | |
| Bromide SCHEMBL6207122 | 0.72 | MTNR1A (0.43) | MAP2K1MAPTMAPK1TDP1HTT | |
| SCHEMBL6237415 | 0.70 | MAP2K1 (0.35) | MAP2K1MAPTTDP1HTTALDH1A1 | |
| SCHEMBL8019409 | 0.64 | EPHX2 (0.49) | MAPTMAPK1ALDH1A1SIGMAR1CYP2C19 | |
| SCHEMBL10884934 | 0.64 | EPHX2 (0.49) | MAPTMAPK1ALDH1A1CYP2C19EPHX2 | |
| SCHEMBL10885758 | 0.64 | EPHX2 (0.49) | MAPTMAPK1ALDH1A1CYP2C19EPHX2 | |
| SCHEMBL10884851 | 0.64 | EPHX2 (0.49) | MAPTMAPK1ALDH1A1CYP2C19EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554250-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004031154-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |