SCHEMBL6237650

SCHEMBL6237650

COc1ncc(C(=O)O)cc1C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
CA1 P00915 3/20 0.40
CA2 P00918 3/20 0.40
KDM4E B2RXH2 3/20 0.40
CA12 O43570 2/20 0.40
CA4 P22748 2/20 0.40
CA6 P23280 2/20 0.40
CA7 P43166 2/20 0.40
CA9 Q16790 2/20 0.40
CA14 Q9ULX7 2/20 0.40
CA3 P07451 1/20 0.40
PKM P14618 1/20 0.40
CA5A P35218 1/20 0.40
CA5B Q9Y2D0 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
ALDH1A1 P00352 1/20 0.40
ALOX15 P16050 1/20 0.40
HSD17B10 Q99714 1/20 0.40
MGAM O43451 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31069006 0.88 KDM4E (0.46) TDP1CA1CA2KDM4ECA12
SCHEMBL26101991 0.88 KDM4E (0.46) TDP1CA1CA2KDM4ECA12
SCHEMBL30647256 0.85 HPGDS (0.49) POLBTDP1KDM4EALDH1A1MAPK1
SCHEMBL18584731 0.85 HPGDS (0.43) KDM4EALDH1A1ALOX15HSD17B10MAPK1
SCHEMBL26101632 0.82 TDP1 (0.36) POLBTDP1KDM4EALDH1A1MAPK1
SCHEMBL26134215 0.82 POLB (0.36) POLBTDP1CA1CA2KDM4E
SCHEMBL26101639 0.82 TDP1 (0.36) POLBTDP1KDM4EALDH1A1MAPK1
SCHEMBL6233391 0.82 MAPT (0.51) KDM4EALDH1A1HSD17B10MAPTP4HTM
SCHEMBL7358042 0.81 PTGS2 (0.50) POLBTDP1CA1CA2KDM4E
SCHEMBL3430654 0.81 HCAR2 (0.44) CA1CA2KDM4ECA12CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1530467-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
EP-1530475-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
WO-2004006931-A2 PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
WO-2004006912-A2 COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed