Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.58 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CPA1 | P15085 | 1/20 | 0.45 |
| ▸ | CPA2 | P48052 | 1/20 | 0.45 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240311 | 1.00 | ACE (0.58) | ACEMMEANPEPTLR2LNPEP | |
| SCHEMBL27458051 | 1.00 | ACE (0.58) | ACEMMEANPEPTLR2LNPEP | |
| SCHEMBL7267746 | 0.90 | ACE (0.65) | ACEMMEANPEPTLR2LNPEP | |
| SCHEMBL5870137 | 0.90 | ACE (0.65) | ACEMMEANPEPTLR2LNPEP | |
| SCHEMBL661267 | 0.90 | ACE (0.65) | ACEMMEANPEPTLR2LNPEP | |
| SCHEMBL5720686 | 0.86 | ACE (0.52) | ACEMMEANPEPTLR2LNPEP | |
| SCHEMBL5720685 | 0.86 | ACE (0.52) | ACEMMEANPEPTLR2LNPEP | |
| SCHEMBL4428775 | 0.85 | ACE (0.53) | ACEANPEPLMNASMN1; SMN2ABCB11 | |
| SCHEMBL4428771 | 0.85 | ACE (0.51) | ACEANPEPLNPEPLMNASMN1; SMN2 | |
| SCHEMBL11008763 | 0.83 | MME (0.68) | ACEMMELMNASMN1; SMN2CPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005010028-A1 | ALPHA-AMINO ACID BENZOTHIAZOLYLTHIO ESTER AS INTERMEDIATES FOR MANUFACTURE OF ACE INHIBITORS AND PROCESS FOR PREPARATION THEREOF | LUPIN LIMITED (IN) | 2005-02-03 | — | — | WO | disclosed |
| EP-0336368-B1 | N2-(1-carboxy-3-phenylpropyl)-L-lysine derivative and process of producing lysinopril using the compound | KANEGAFUCHI CHEMICAL IND (JP) | 1995-02-01 | — | — | EP | disclosed |
| EP-0336368-A2 | N2-(1-carboxy-3-phenylpropyl)-L-lysine derivative and process of producing lysinopril using the compound | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-10-11 | — | — | EP | disclosed |