Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.53 |
| ▸ | CTSK | P43235 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSH | P09668 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064947 | 0.87 | ACE (0.49) | ACECTSKSMN1; SMN2ANPEPLMNA | |
| SCHEMBL6064398 | 0.87 | ACE (0.70) | ACECTSKCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL27458051 | 0.85 | ACE (0.58) | ACESMN1; SMN2ANPEPLMNAABCB11 | |
| SCHEMBL6240311 | 0.85 | ACE (0.58) | ACESMN1; SMN2ANPEPLMNAABCB11 | |
| SCHEMBL6237696 | 0.85 | ACE (0.58) | ACESMN1; SMN2ANPEPLMNAABCB11 | |
| SCHEMBL4428771 | 0.82 | ACE (0.51) | ACESMN1; SMN2ANPEPLMNACHRNB2 | |
| SCHEMBL497024 | 0.79 | SMN1; SMN2 (0.56) | ACESMN1; SMN2LMNAABCB11MEN1 | |
| SCHEMBL10834443 | 0.79 | SMN1; SMN2 (0.56) | ACESMN1; SMN2LMNAABCB11MEN1 | |
| SCHEMBL8301017 | 0.79 | TLR2 (0.51) | ACESMN1; SMN2LMNACHRNB2CHRNB4 | |
| SCHEMBL14374305 | 0.76 | ACE (0.60) | ACESMN1; SMN2LMNAABCB11MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635816-B1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX SA (FR) | 2009-03-04 | — | — | EP | disclosed |
| EP-1635816-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Nicox S.A. (FR) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110432-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX S.A. (FR) | 2004-12-23 | — | — | WO | disclosed |